Associate Director, Proteomics

How will your role help us transform hope into reality?

We are seeking an accomplished and driven proteomics scientist to join our team at the Associate Director level. The ideal candidate is an expert in quantitative proteomics with a solid background in mass spectrometry research and a proven track record in advancing drug discovery projects through proteomics. In this role, you will leverage your expertise to drive innovation in proteomics capabilities and strengthening our targeted protein degradation platform. Working closely with computational biology experts, you’ll enhance informatics workflows for comprehensive data capture, analysis, and archiving, enabling in-depth and cross-study analysis.

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Desirable experience includes both global and targeted proteomics studies on the ubiquitin-proteasome pathway, characterization of PROTACs or molecular glue degraders, and protein interactome analysis. Experience in ubiquitinomics, affinity- or crosslinking techniques, or proximity labeling-based chemical proteomics is also highly desirable

What will you do?

• As part of the proteomics team you will identify, evaluate, and implement latest technologies and expand internal proteomics capabilities, in alignment with discovery project needs.
• Collaborate with the computational biology team to optimize workflows for data management and in-depth analysis.
• Design, execute, and interpret experiments that address key challenges in our drug discovery initiatives.
• Perform data analysis, share results, and present findings to project and department teams, providing insights and recommendations.
• Explain relevant methodologies, applications, and limitations effectively to colleagues from other scientific disciplines.
• Develop strategies to deepen proteomics integration into drug discovery, enhancing both precision and throughput, taking innovative approaches to address evolving challenges.
• Potential to lead the proteomics team based on people management experience.

What minimum qualifications do we require?

• Ph.D. in Biochemistry, Chemical Biology, Analytical Chemistry, or a related field with 5+ years of post-graduate experience, or an M.S. degree with 8+ years of research experience.

What additional qualifications will make you a stronger candidate?

• Proteomics Expertise: Solid understanding of proteomics methodologies, including labeled and label-free quantification techniques and post-translational modifications, such as ubiquitination. Hands-on experience in setting up, operating, developing methods, and troubleshooting liquid chromatography and mass spectrometry systems from various instrument vendors. Skilled in sample preparation, data acquisition, and analysis, with proficiency in latest proteomics data analysis software. Experience in targeted protein degradation or ubiquitin-proteasome system biology highly desirable.
• Additional Laboratory Skills: Practical knowledge of cell culture, affinity pull-down or other chemical biology methods preferred but not required. Experience in sample handling automation a plus.
• Drug Discovery Experience: Good understanding of, and passion for the drug discovery process.
• Commitment to Blueprint Medicines’ Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to [email protected]. 

For more information, please see our EEO-AA Policy Statement, the EEO Know Your Rights Poster, as well as our Pay Transparency Statement. 

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

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