Enzyme Development Scientist

Job Description

As a leading innovator of women's health, we at Hologic are empowering people to live healthier lives everywhere, every day.

R&D is the engine of our business here at Hologic, our R&D teams sit at the cutting edge of technology, our innovations are designed to achieve exceptional clinical results making it possible to detect, diagnose and treat illnesses and other health conditions earlier and with more certainty.

The R&D Assay Product Development team is looking for a candidate with considerable experience in protein biochemistry and assays and will function closely with a team of scientists to design processes for manufacture of proteins and related reagents. The candidate will join the Platform technology and Advanced Research group and will be responsible for developing wide-ranging knowledge in enzymes and associated protein/antibody systems applicable to Hologic's Diagnostic Assays and Technology.

So, what will you do?

The Scientist 2, Enzyme Development is responsible for development and transfer of protein systems, including Enzymes and Antibodies. The position will work in collaboration with other departments and external stakeholders to develop all aspects of product development including specification setting, root cause investigations, test method development, transfer to manufacturing, on-market support, and other activities to ensure the robustness and performance of Hologic Diagnostic Assays.

• Develop robust, scalable protein purification processes suitable for transfer to manufacturing
• Purify proteins using column chromatography and filtration techniques
• Perform functional and physical assays to assess protein purity and stability
• Develop, generate, and verify buffer systems to support specific design requirements
• Thoroughly and accurately document experiments as they are performed
• Curate samples and generate process development reports
• Help troubleshoot unexpected or challenging results within a team
• Optimize and stress test process designs to ensure robust performance
• Analyze, summarize, and present results to teams to drive design decisions and improvements
• Provide guidance to other departments to ensure success of projects
• May interact with upper management in communicating project status, issues, and resourcing
• Feasibility, Assay design and transfer, formulation optimization and transfer, assay integration or V&V
• Engages cross-functionally (Operations, Commercial, Regulatory, Quality, other R&D) to achieve Program goals
• May be an independent contributor or supervise a team

We would like you to have:

• Knowledge of FDA, IVDR, and ISO regulations related to in-vitro diagnostics preferred
• Experience in Specification setting, Method development and transfer, and formal risk assessments
• Working knowledge of enterprise tools, including electronic document & records management tools (SAP, Oracle, Agile), Microsoft office, JMP

Required Education and Experience:

• BS with minimum 5 years, MS with minimum 3 years, or PhD with 0-3 years experience in Biochemistry, Molecular Biology, Microbiology, Chemistry, Chemical Engineering, Biomedical Engineering, or related field
• Experience in analyzing proteins and nucleic acids using techniques such as SDS-PAGE, agarose gel electrophoresis, UV/Vis spectroscopy, fluorescence-based assays, or protein or nucleic acid quantitation
• Familiarity with column chromatography techniques such as IMAC, affinity, ion exchange, hydrophobic interaction, or size exclusion chromatography
• Familiarity with filtration techniques such as microfiltration, depth filtration, or tangential flow filtration
• Experience with automated purification
• Experience with buffer formulation for proteins and understanding of the chemical properties of salts, chelators, biological buffers, and reducing agents

Key additional requirements for us are:

• Innovation: uses expertise and knowledge to provide high level perspective and innovative solutions to major projects
• Judgement: combines expertise with experience to provide high level perspective and solutions to major projects
• Strategic Thinking: manages priorities and secures support needed from other functions to complete the tasks
• Planning: Identifies specific action steps, accountabilities, and timelines for completion of projects and provides accurate estimates for project resources and budget
• Managing people: Manages or influences people in a constructive manner to achieve strategic and personal goals
• Leadership: guides the technical aspects of projects and has courage to course correct even if it is difficult
• Communication: distills complex technical information and delivers it to leadership so they can make effective decisions

Why join Hologic?

We are committed to making Hologic the destination for top talent. For you to succeed, we want to enable you with the tools and knowledge required and so we provide comprehensive training when you join as well as continued development and training throughout your career.

From a benefits perspective, you will have access to benefits such as medical and dental insurance, ESPP, 401(k) plan, vacation, sick leave and holidays, parental leave, wellness program and many more!

We can't wait to hear from you!

The annual base salary range for this role is $93,000 to $145,500 and is bonus eligible. Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, geography, education, business needs and market demand.

Agency and Third Party Recruiter Notice:

Agencies that submit a resume to Hologic must have a current executed Hologic Agency Agreement executed by a member of the Human Resource Department. In addition Agencies may only submit candidates to positions for which they have been invited to do so by a Hologic Recruiter. All resumes must be sent to the Hologic Recruiter under these terms

or they will not be considered.

Hologic, Inc. is proud to be an Equal Opportunity Employer inclusive of disability and veterans.