Principal/Sr. Principal Scientist-ADME-FDE

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

The Bioanalytical Research Group (BAR) at the Lilly Corporate Center, Indianapolis, IN is seeking a scientist skilled in ligand-binding assay (LBA) development to evaluate the ADME of therapeutic proteins and new modalities such as RNA-based therapeutics and antibody-drug-conjugates.

The team collaborates with toxicology, PK/PD, protein engineering, and multiple therapeutic areas to help discover and characterize optimal therapeutic candidates to advance to clinical testing.

Are you looking to join a company passionate about innovation and impacting patients? Apply today and join the Lilly family!

Responsibilities:

The primary responsibilities for this position include:

• The development and application of immunoassays to measure complex therapeutic proteins and RNA-based medicines in a wide variety of biological matrices, including tissues.
• Investigating mechanistic questions related to target engagement, biodistribution, and immunogenicity of therapeutic proteins.
• Serving as the Bioanalytical Project Lead for sophisticated projects requiring input from a highly qualified scientist on PK, PD, and immunogenicity assays. Additionally, to lead the interpretation of bioanalytical data provided to project teams.

Basic Requirements:

• B.S. in biochemistry, molecular biology, biology, chemistry, or equivalent expertise, with 5+ years of relevant proven experience (or an M.S. with 3+ years) in bioanalysis using immunoassays.

Additional Information:

• This position is not permanent. It is for a fixed duration of 1 year.

Additional Skills/Preferences:

• Solid understanding of assay development and implementation using a diverse range of immunoassay technologies such as sandwich ELISA, MSD, and/or Gyros.
• Knowledge of the ADME of therapeutic proteins.
• An understanding of the principles and methods used to assess ADA.
• Experience in the use of flow cytometry, qPCR, and/or cell culture.

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