Scientist II, Editing Discovery

The Position

Verve is seeking a Scientist II with experience in developing CRISPR-Cas9 based gene editing technologies, with a particular emphasis on analyzing gene editing outcomes. This individual will help advance our early research efforts to preclinical and clinical development using cellular and animal models. They will have the opportunity to translate basic research findings into novel therapeutic strategies that may eventually support clinical drug development.

We are considering local candidates at this time. 

Job Responsibilities

• Design and execute molecular and cell-based assays to advance our development programs. Including use of enzymatic/PCR based methods (RT-PCR, qRT-PCR, standard, etc) to assess gene editing outcomes using next generation sequencing.
• Write protocols, perform experiments, organize data, analyze data, interpret results, and record experiments in an electronic lab notebook, and summarize work in presentations and technical reports.
• Independently lead and run laboratory experiments to support and advance discovery efforts.
• Conduct research across the gene editing field to develop techniques in-house.
• Propose and implement new techniques for on- and off-target gene editing analysis.
• Collaborate with multiple cross-functional teams, including analytical development, Editor development, NGS, and bioinformatics.
• Training and mentoring of more junior team members.
• Other duties as assigned.

Qualifications

• Ph.D. in Biochemistry, Molecular biology, Cell biology or related fields with at least 2 years of relevant industry experience or;
• M.S. in Biochemistry, Molecular biology, Cell biology or related fields with at least 7 years of relevant industry experience or;
• B.S. in Biochemistry, Molecular biology, Cell biology or related fields with at least 9 years of relevant industry experience.
• Experience with gene editing and/or advanced molecular biology strongly preferred.
• Advanced experience in mammalian cell culture required.
• Strong molecular biology experience, proficiency in PCR, RT-PCR, qPCR, ddPCR and protein quantification.
• Knowledge of current gene-editing approaches used in a therapeutic context.
• Experience with next-generation sequencing library prep is desirable.
• Strong analytical and problem-solving abilities, excellent communication, and interpersonal skills.
• Collaborative and detail-oriented approach to efficient performance across multiple teams and projects in a highly matrixed environment.