Scientist/Senior Scientist

Alpine Immune Sciences is a leading clinical-stage biopharmaceutical company dedicated to discovering and developing innovative, protein-based immunotherapies for autoimmune and inflammatory diseases. Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges. Join us!

This Scientist/Senior Scientist will be responsible for bioanalytical assay development and biological sample analysis to support our protein-based immunotherapeutic platforms from discovery through clinical development. The successful candidate will have extensive knowledge of and a proven track record in supporting pharmacokinetic, immunogenicity and biomarker studies. This individual will also be involved in the identification and implementation of new technologies and strategies to streamline workflows.

Duties and responsibilities

• Design, develop, qualify, and implement ligand binding assays independently with minimal supervision for PK, TK, ADA and PD support in various species and biological matrices.

• Focus on implementation and outsourcing of clinical biomarker assays (ligand binding assays) to measure soluble ligands and receptors.

• Develop and implement sample preparation strategies to remove, separate, or enrich drug, ADA, or soluble counter-structures from biological matrices.

• Resolve bioanalytical issues and assist junior colleagues in troubleshooting.

• Play an important role in maintaining critical reagent inventory, and authoring assay methods and work instructions.

• Analyze, summarize, and present data in group meetings and contribute to scientific discussions.

• Interact with multidisciplinary teams to meet project goals and timelines.

• Maintain a clear, detailed electronic laboratory notebook to document all experiments and findings.

Qualifications

• BS or MS degree in Bioanalytical Chemistry, Biochemistry, Biology or related discipline with a minimum of seven years relevant research/industry experience.

• Demonstrated experience in development of bioanalytical assays and interpretation of data is required.

• Understanding and ability to implement FDA and EMA bioanalytical guidance in a GxP-like environment.

• Experience in oversight of assay development or transfer as well as validation at multiple CROs is a plus.

• Strong problem solver who is highly organized with the ability to multitask and thrive in an environment with rapidly changing priorities.

• Excellent interpersonal skills with an ability to collaborate and successfully operate within a high functioning team.

• Proficient with MS Word, MS PowerPoint, and data analysis software (e.g., MS Excel, SoftMax Pro, GraphPad Prism, and/or Discovery Workbench).

• Experience with electronic notebooks and LIMS is desired.

#LI-Onsite

At Alpine we engage equitable workplace strategies to ensure fair compensation. Actual compensation is dependent upon current market data, experience, and pay parity within our organization. This position is a professional level position with a compensation range of $105,000 to $130,000 for a Scientist and $125,000 to $150,000 for a Senior Scientist. In order to be considered for a position, candidates must be located in one of the following five states: CA, MA, NC, OR, or WA. We take care of our employees with a competitive benefits package that includes stock options, annual bonus, premium medical, dental, and vision coverage for employees and their dependents, as well as life and disability benefits, FSA, and 401(k) plans. We believe quality time outside the office is vital to our employees’ satisfaction at work, so our flexible PTO plan of 160 hours, generous holiday time (generally 12 days), and parental benefits encourages team members to take time off so they can come back refreshed. Alpine team members enjoy competitive salaries and equity participation (stock options).

Alpinists share a passion for meaningful work and are committed to solving the most complex problems in immunology to create new therapies for patients. We believe in innovative thinking, collaboration, flexibility, bias for action, and healthy debate. To foster our team of outstanding scientists and business professionals, we provide a premier work environment with a state-of-the-art lab and office spaces with truly inspiring views, and an open design to facilitate teamwork.

Our treasured culture has been shaped by our diverse team who truly enjoys working and playing together. We nurture Alpine’s culture in many ways, including all-company social events and happy hours, lunch-and-learn and education opportunities, interest groups like book club and movie nights, peer-to-peer recognition programs, a robust wellness program to help support physical, mental, and emotional health, and more.

Alpine is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. Alpine is also committed to compliance with all fair employment practices regarding citizenship and immigration status.

Our office and lab are located in the blossoming biotech neighborhood of Eastlake in Seattle. Alpinists enjoy the flexibility to work onsite, remotely, or a hybrid schedule, with evolving options as we prioritize keeping Alpinists safe and healthy. Onsite employees enjoy an open-office layout with comfortable huddle rooms and Zoom Room-enabled conference rooms, a spacious breakroom and kitchen with a coffee bar and snacks, and rooftop access to enjoy gorgeous views of Lake Union and Gas Works Park.

Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges. Join us!