Senior Research Associate, Biotherapeutics

Sr Research Associate, Biotherapeutics

About the role

We are seeking an enthusiastic, and highly motivated scientist to join our team. With a background in conjugation, purification and analytical characterization of antibody drug conjugates (ADCs), and a track record of contributing to multidisciplinary drug discovery teams, this position will play a critical role in driving Treeline’s portfolio forward.  You will also play a key role in developing the next generation of ADCs using bioconjugation, biochemistry, analytical chemistry techniques and various state-of-the-art scientific approaches. You will closely collaborate with other biochemists, medicinal chemists, biologists, and pharmacologists to enable forward progress of drug discovery programs.

Responsibilities

• Perform, develop and optimize conjugation methods to generate high quality ADCs to support drug discovery campaigns.
• Conduct routine purification and analytical characterization of ADCs.
• Evaluate physicochemical properties, stability and developability of lead ADC candidates.
• Design and conduct well controlled high-quality experiments to answer key scientific questions.
• Contribute to evaluation and development of new approaches and technologies within the bioconjugation group.
• Closely collaborate with medicinal chemistry, protein science and biology teams.
• Maintain an electronic lab notebook in compliance with company policies.
• Help establish the bioconjugation group and contribute to building a culture that embraces continuous learning and improvement.

Qualifications

• BS or MS in Biochemistry, Chemistry, or related discipline with at least two years of experience in antibody conjugation.
• Experience with purification and analytical characterization of ADCs using AKTA, UF/DF, UV-Vis, LC-MS, SEC, SDS-Page is required.
• Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on cross-functional, multidisciplinary teams.

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