Senior Scientist

Company Description

LGC Clinical Diagnostics is a leading and trusted global manufacturer of Quality Management Tools (QMT) and reagent components. We partner with In Vitro Diagnostics (IVD) and biopharmaceutical developers, clinical research organizations (CROs) and academic institutions in commercialization activities across the entire diagnostic pipeline - from concept and early-stage research, through expedited product development and onwards into routine clinical use. Laboratories and diagnostic professionals across disciplines of clinical chemistry, immunochemistry, serology, molecular diagnostics, and clinical genomics rely on LGC’s products to achieve accurate and reliable diagnostic results.

Our combined and ever-growing capabilities mean we are better positioned to support the needs of the clinical diagnostics industry, from early feasibility and research to commercial & laboratory development test (LDT) assay development, installation, validation and ongoing performance monitoring support. LGC Clinical Diagnostics Quality Management and reagent component manufacturing facilities are FDA-registered, and ISO 13485 and ISO 9001-certified.

Our brands include five IVD manufacturers of QMTs and one manufacturer of viral and bacterial antigens and antibodies:

• Technopath Clinical Diagnostics Independent Quality Controls & QC Software Solutions
• SeraCare Quality Controls, Reference Materials, Biological Materials, reagent components
• Biochemical Diagnostics Drugs of Abuse Quality Control
• Kova International Urinalysis Quality Control
• Maine Standards Company Calibration verification materials, validation & qualification panels, calibrators, and OEM PT/EQA samples
• The Native Antigen Company Viral and bacterial antigens/antibodies

Job Description

Job Purpose

As a member of the Technology Development group, the Scientist role will focus primarily on the creation and characterization of prototypes of novel products that solve challenges with measurement in Immunology and Hematology as well as determining the feasibility of manufacturing such products.

Key Responsibilities

• Evaluating and implementing technologies that are necessary to accomplish this.
• Supporting others within and outside of the group by applying these technologies.
• Training others to support you and – as part of design transfer – training others when a product you developed ends up being manufactured.
• Keeping up to date on clinical assays that are used in Immunology and Hematology as well as the measurement challenges associated with these assays.
• Training on any required SOPs (we are a regulated medical device manufacturer).

Knowledge, Experience and Technical Skills

• Mammalian cell culture and associated sterile technique.
• Working with human BSL2 samples in a biosafety cabinet.
• Flow cytometry and fluorescence microscopy for quantifying and characterizing extracellular and intracellular markers.
• FACS for sorting defined numbers of cells (including single cells) based on markers that can then be characterized by using additional methods such as Next Generation Sequencing (NGS).
• Cell-based in vitro assays for looking at the functions of cells.
• Comfortable with Math and Statistics and programs and algorithms that can be used to analyze large datasets; many of the measurement challenges involve separating signals from noise.
• Committed to finding brilliant ways to solve difficult problems (for example, how do you make a consistent product from cells that differ each time?).
• Ability to work independently and collaborate effectively in teams with high integrity and respect.
• Curious and seeking continuous learning as well as the development and improvement of new and existing technologies.
• Ability to work passionately on multiple projects and to be willing to reprioritize them as needed.

Qualifications

Education and/or Experience

• Ph.D. (preferred) in Immunology or a related field that provided laboratory experience in cell culture and the analysis of cells.
• At least 5 years hands-on laboratory experience in cell culture and the analysis of cells.
• Knowledge of Immunology and Hematology and the measurement challenges in these fields (e.g., detection of transplant rejection, lymphoma, minimal residual disease, etc.).
• Demonstrated experience adapting one or more technologies to solving a new problem.

Additional Information

All your information will be kept confidential according to EEO guidelines.