Senior Scientist / Principal Scientist, DMPK

Company Overview: 

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Vividion was ranked #2 mid-size company on The San Diego Union-Tribune's 2022 Top Workplaces list.

Job Summary: 

A successful candidate will be expected to use your expertise to design and execute in vitro/in vivo studies to elucidate the absorption, distribution, metabolism, excretion (ADME) properties of our covalently and non-covalently targeted small molecules. You will work closely within DMPK team and with multidisciplinary drug discovery teams providing expert input to overcome in vitro and in vivo DMPK challenges and progress small molecule therapeutics to IND. You will help design, execute, interpret, and report studies involving small molecules delivered by a variety of routes in several pre-clinical species. This individual will be a key team member to support lead candidate identification and advancement in collaboration with colleagues in multidisciplinary teams. Modeling human PK performance may also be involved.

Essential Duties and responsibilities:

• Represent DMPK group as a subject matter expert in small molecule drug discovery and development projects and provide guidance to project teams to characterize, select and advance covalently and non-covalently targeted small molecule drug candidates
• Collaborate with discovery project teams to design and implement mechanistic studies to understand absorption and clearance mechanisms in non-clinical species and in human, and to address current and future ADME related challenges
• Hands on experience in designing, managing, developing and performing in vitro ADME assays, such as metabolic stability, permeability, CYP inhibition/induction, CYP/non-CYP phenotyping, metabolic profiling in different biological matrices. Being able to interpret and extract information to support Chemists in drug design and SAR work as well as guide project teams select and advance lead candidates
• Supervise and mentor research associate(s) to develop and implement in-house in vitro ADME assays 
• Manage and oversee the execution of internal and external in vitro ADME studies to ensure high quality of delivery. Review and evaluate study protocols, results and summary reports prior to releasing to project teams.
• Identify, introduce new technologies and lead new method development efforts to address current and future ADME related challenges
• Perform bioanalytical data and in vivo PK data review, non-compartmental analysis (NCA), write and present PK and TK summary reports to project teams
• Contribute to the writing of IND filing related documents

Education and Experience requirements:

• Ph.D. in drug metabolism, pharmacokinetics or a closely related discipline 
• 8+ years of experience in DMPK-related positions within a pharmaceutical or biotechnology company 
• An in-depth understanding of all aspects of DMPK with experience in drug discovery settings 
• In-depth understanding of in vitro and in vivo ADME assays, methods, and models
• Assist in the design, conduct, and data interpretation of in vitro and in vivo pharmacokinetic/toxicokinetic, ADME and in vitro drug-drug interaction studies
• The ability to work in team-based drug discovery/development environments is required 
• Must be able to design and perform both routine and mechanistic in vitro and in vivo studies 
• Hands on experience with different biological samples and sample preparation techniques to generate qualitative and quantitative data along with operation of HPLC and LC/MS/MS instrumentation is highly desired 
• Experience with in vitro ADME assay and pre-clinical pharmacokinetic study protocol design
• Experience working with CROs

Required Key Attributes: 

• Interpersonal skills that support team dynamics, highly collaborative 
• Curiosity around outcomes and a willingness to dig deep into data
• Solid problem-solving and effective communication skills
• Solution and result-oriented focus and attention to details 
• Open to diverse points of view

Pay & Benefits: 

The annual base salary for this position ranges from $150,000 to $175,000 depending on relevant skills, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance. Relocation assistance may be available based on business needs and/or eligibility.

EEO & Employment Eligibility:

Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Privacy Policy:

The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/publication/privacy-noticeforcalifornia-candidates/.